Mast cells have existed long before the development of adaptive immunity, although they
have been given different names. Thus, in the marine urochordate Styela plicata, they have …

Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Macrophages populate every organ during homeostasis and disease, displaying features of
tissue imprinting and heterogeneous activation. The disconnected picture of macrophage …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Mast cells can promote inflammation and other tissue changes in IgE-associated allergic
disorders, as well as in certain innate and adaptive immune responses that are thought to be …

Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases.
However, over the last decade our understanding has been enriched about their roles in …

IL-17 is a pivotal proinflammatory molecule in asthmatics. However, the cellular source of IL-
17 in asthma has not been identified to date. In this study, we report that macrophages rather …

The identification of novel helper T (Th) cell subsets, ie, IL-17-producing Th cells (Th17 cells)
and regulatory T cells (Treg cells), provided new insight into our understanding of the …

Mast cells (MC) are a bone marrow-derived, long-lived, heterogeneous cellular population
that function both as positive and negative regulators of immune responses. They are …

In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute
IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of …