New antiparasitic drugs are urgently needed to treat and control diseases such as malaria,
leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year …

▪ Abstract The increase in drug-resistant pathogenic bacteria has created an urgent demand
for new antibiotics. Among the more attractive targets for the development of new …

The present review focuses on microbial type I fatty acid synthases (FASs), demonstrating
their structural and functional diversity. Depending on their origin and biochemical function …

▪ Abstract Phospholipids play multiple roles in bacterial cells. These are the establishment of
the permeability barrier, provision of the environment for many enzyme and transporter …

The β-ketoacyl-acyl carrier protein (ACP) synthases are key regulators of type II fatty acid
synthesis and are the targets for two natural products, thiolactomycin (TLM) and cerulenin …

Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are
inadequate due to toxicity, the development of drug resistance and an inability to eliminate …

Fatty acid biosynthesis, the first stage in membrane lipid biogenesis, is catalyzed in most
bacteria by a series of small, soluble proteins that are each encoded by a discrete gene (Fig …

The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause
important diseases in humans. These include Trypanosoma brucei (the causative agent of …

Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced
by numerous factors, including extracellular environmental signals, nutrient availability and …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: sleeping sickness, Chagas diseases and leishmaniasis …