In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost.—RT …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

In this study, we demonstrate that:(i) injection of an adenovirus (Ad) vector containing the
brain-derived neurotrophic factor (BDNF) gene (Ad. BDNF) into the vitreous chamber of …

Clinical and experimental evidence indicate that physical activity has a positive impact on
brain function; however, the molecular bases for how exercise affects the structure and …

Publisher Summary Plasticity is an essential characteristic of the brain. It is part of the ways
in which the brain functions and is continuous while the brain interacts with the outer world …

The effects of normal aging on the primate brain are incompletely understood. Although both
human and nonhuman primates demonstrate clear functional declines in selective …

The purpose of this study was to evaluate the therapeutic effects of the transplantation of
bone-marrow mesenchymal stem cells (MSCs), genetically engineered to over-express …

In the present study, F-344 rats throughout 1.5 to 26 months of age were tested in the
reference memory version, a moving-platform repeated acquisition version, and in a cued …

The study of the basic physiology of the neural precursors generated during brain
development is driven by two inextricably linked goals. First, such knowledge is instrumental …