Molecular quantitative trait loci
Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …
genetics, as much of disease-associated variation is located in non-coding regions with …
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies
provides an attractive solution to the problem of collecting large sample sizes for discovering …
provides an attractive solution to the problem of collecting large sample sizes for discovering …
Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome
KE Johnson, T Heisel, M Allert, A Fürst, N Yerabandi… - Cell Genomics, 2024 - cell.com
Human milk is a complex mix of nutritional and bioactive components that provide complete
nourishment for the infant. However, we lack a systematic knowledge of the factors shaping …
nourishment for the infant. However, we lack a systematic knowledge of the factors shaping …
Gene expression and splicing QTL analysis of blood cells in African American participants from the Jackson Heart Study
Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies
have been biased toward European ancestry individuals. Here, we performed eQTL and …
have been biased toward European ancestry individuals. Here, we performed eQTL and …
Modern Statistical Methods for Genetics and Genomic Studies
X Li - 2021 - search.proquest.com
Recent scientific advances in genetics and genomic studies have enabled the
characterization and prediction of functional genomic elements across the human genome …
characterization and prediction of functional genomic elements across the human genome …
Identification of Potential Molecular Traits Underlying the Genetic Predisposition to Complex diseases Using Multi-omics and Meta-analysis
L Guan - 2021 - deepblue.lib.umich.edu
Complex diseases are multifactorial diseases caused by a complex combination of genetic,
environmental and lifestyle effects. Numerous non-coding regions that increase the risk for …
environmental and lifestyle effects. Numerous non-coding regions that increase the risk for …
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
KA Broadaway, SM Brotman, JD Rosen… - The American Journal of …, 2024 - cell.com
Understanding the molecular mechanisms of complex traits is essential for developing
targeted interventions. We analyzed liver expression quantitative-trait locus (eQTL) meta …
targeted interventions. We analyzed liver expression quantitative-trait locus (eQTL) meta …