Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …

[HTML][HTML] Cerebral palsy—trends in epidemiology and recent development in prenatal mechanisms of disease, treatment, and prevention

M Stavsky, O Mor, SA Mastrolia, S Greenbaum… - Frontiers in …, 2017 - frontiersin.org
Cerebral palsy (CP) is the most common motor disability in childhood. This syndrome is the
manifestation of intrauterine pathologies, intrapartum complications, and the postnatal …

[HTML][HTML] Preterm birth and sustained inflammation: consequences for the neonate

A Humberg, I Fortmann, B Siller, MV Kopp… - Seminars in …, 2020 - Springer
Almost half of all preterm births are caused or triggered by an inflammatory process at the
feto-maternal interface resulting in preterm labor or rupture of membranes with or without …

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

R Romero, J Miranda, P Chaemsaithong… - The journal of …, 2015 - Taylor & Francis
Objective: The objectives of this study were to:(1) determine the amniotic fluid (AF)
microbiology of patients with preterm prelabor rupture of membranes (PROM); and (2) …

The fetal inflammatory response syndrome

R Gomez, R Romero, F Ghezzi, BH Yoon… - American journal of …, 1998 - Elsevier
OBJECTIVE: The objective of this study was to determine the frequency and clinical
significance of a systemic inflammatory response as defined by an elevated plasma …

The role of inflammation and infection in preterm birth

R Romero, J Espinoza, LF Gonçalves… - Seminars in …, 2007 - thieme-connect.com
Inflammation has been implicated in the mechanisms responsible for preterm and term
parturition, as well as fetal injury. Out of all of the suspected causes of preterm labor and …

The consequences of chorioamnionitis: preterm birth and effects on development

R Galinsky, GR Polglase, SB Hooper… - Journal of …, 2013 - Wiley Online Library
Preterm birth is a major cause of perinatal mortality and long‐term morbidity.
Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis …

The fetal inflammatory response syndrome

F Gotsch, R Romero, JP Kusanovic… - Clinical obstetrics and …, 2007 - journals.lww.com
The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic
inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been …

Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury

R Romero, F Gotsch, B Pineles… - Nutrition reviews, 2007 - academic.oup.com
Fetal development and growth occur in a sterile amniotic cavity while first exposure to
microorganisms happens at birth. However, at least 25% of all preterm births, the leading …

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

BH Yoon, R Romero, JY Park, KJ Oh, JH Lee… - American journal of …, 2019 - Elsevier
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …