Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis
I Kekessie, K Wegner, I Martinez… - The Journal of …, 2024 - ACS Publications
Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many
attractive targets are poorly tractable by small molecules, generating a need for new …
attractive targets are poorly tractable by small molecules, generating a need for new …
[HTML][HTML] Stapled peptides as potential therapeutics for diabetes and other metabolic diseases
D Nielipińska, D Rubiak, AJ Pietrzyk-Brzezińska… - Biomedicine & …, 2024 - Elsevier
The field of peptide drug research has experienced notable progress, with stapled peptides
featuring stabilized α-helical conformation, emerging as a promising field. These peptides …
featuring stabilized α-helical conformation, emerging as a promising field. These peptides …
In silico prediction of GLP-1R agonists using machine learning approach
ZK Kuang, XY Cheng, ZX Yang, YX Guo, YQ Huang… - Chemical Papers, 2021 - Springer
Glucagon-like peptide 1 receptor (GLP-1R) is a well-known drug target for the treatment of
type 2 diabetes mellitus (T2DM). However, the currently marketed peptidyl GLP-1R agonist …
type 2 diabetes mellitus (T2DM). However, the currently marketed peptidyl GLP-1R agonist …
Design and Implementation of a Glucose-Responsive Genetic Switch Circuit in Cell-Free Systems for the Management of Diabetes
A Adhikari - 2023 - search.proquest.com
Cell-free protein synthesis (CFPS) systems are a widely used research tool in systems and
synthetic biology and a promising platform for manufacturing of proteins and chemicals …
synthetic biology and a promising platform for manufacturing of proteins and chemicals …