Most common diseases are complex genetic traits, with multiple genetic and environmental
components contributing to susceptibility. It has been proposed that common genetic …

Venous thrombosis occurs in about 1 per 1,000 individuals per year. 1, 2 It usually affects
the deep veins of the leg, but may occur in other sites, such as the upper extremities …

Context: It has been suggested that elevated total plasma homocysteine levels are
associated with the risk of venous thrombosis. Objective: To assess the relationship of …

Background Venous thromboembolism is a leading cause of morbidity and mortality during
pregnancy and the puerperium. However, the role of mutations in the prothrombin and factor …

Genetic and environmental factors interact in determining the risk of venous
thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor …

High plasma levels of homocysteine are the results of the interplay between congenital and
environmental factors. In the last two decades, a growing amount of interest has focused on …

Both markedly and mildly elevated circulating homocysteine concentrations are associated
with increased risk of vascular occlusion. Here we review possible mechanisms that mediate …

We conducted a systematic and comprehensive meta-analysis on all candidate genes to
assess their genetic contribution to the aetiology of venous thromboembolism …

Over the last decade we have witnessed an avalanche of newly identified risk factors for
venous thrombosis. This has advanced our knowledge of its etiology, because more …

An association between fetal loss and thrombophilia has recently been described but has
not been yet fully elucidated. We have evaluated prospectively the prevalence of the three …