As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …

Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans
(PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and …

The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …

Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often
opposing functions. The biological activities of this polysaccharide depend on its molecular …

Tumors are cellular masses formed through dynamic interactions between tumor cells and a
mixed population of stromal cells. Crosstalk between oncogenic and adjacent stromal cells …