Chemoresistance remains the foremost challenge in cancer therapy. Targeting reactive
oxygen species (ROS) manipulation is a promising strategy in cancer treatment since tumor …

Abstract Heme oxygenase‐1 (HO‐1) is the only way for cells to decompose heme. It can
cleave heme to produce carbon monoxide (CO), ferrous iron (Fe2+), and biliverdin (BV). BV …

Hemoglobin and iron overload is considered the major contributor to intracerebral
hemorrhage (ICH)-induced brain injury. Accumulation of iron in the brain leads to microglia …

Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the
tumors with poorer prognosis. Recently, the role of the oncometabolite lactate has become …

Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic
alterations in MDS patients strictly correlate with microenvironment dysfunctions, eventually …

Metabolic changes of malignant plasma cells (PCs) and adaptation to tumour
microenvironment represent one of the hallmarks of multiple myeloma (MM). We previously …

Tumor onset and its progression are strictly linked to its metabolic rewiring on the basis of
the Warburg effect. In this context, fumarate emerged as a putative oncometabolite …

Background: Chronic myeloid leukemia is a hematological malignancy characterized by the
abnormal proliferation of leukemic cells. Despite significant progress with tyrosine kinase …

Multiple myeloma (MM), the second most common hematological malignancy, is generally
considered incurable because of the development of drug resistance. We previously …

Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical
applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting …