During its fourth transporter workshop in 2021, the International Transporter Consortium
(ITC) provided updates on emerging clinically relevant transporters for drug development …

The kidney functions not only as a metabolite elimination organ but also plays an important
role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and …

Background With the availability of second-generation androgen receptor inhibitors
(SGARIs), the treatment landscape has changed dramatically for patients with nonmetastatic …

Furosemide (FUR) has been used in probe drugs cocktails for in vivo evaluation of the renal
transporters OAT1 and OAT3 activities in studies of drug-drug interactions (generally using …

Bovine casein is considered as an important source of many bioactive peptides (BAPs),
which can also be produced via in vitro simulated gastrointestinal hydrolysis. To perform …

Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact
of inflammation on renal drug transporters remains to be elucidated. We aimed to quantify …

Purpose The tissue-to-plasma partition coefficient (K p) describes the extent of tissue
distribution in physiologically-based pharmacokinetic (PBPK) models. Constant-rate infusion …

Poor and variable oral bioavailability of furosemide (FUR) presents critical challenges in
pharmacotherapy. We investigated the interplay of breast cancer resistance protein (Bcrp) …

Pregnant women are frequently prescribed drugs to treat chronic diseases such as human
immunodeficiency virus infection, but little is known about the benefits and risks of these …

The liver plays a pivotal role in drug disposition owing to the expression of transporters
accounting for the uptake at the sinusoidal membrane and the efflux across the basolateral …