Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Accurate predictions of the three-dimensional structures of proteins from their amino acid
sequences have come of age. AlphaFold, a deep learning-based approach to protein …

Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …

Nuclear magnetic resonance (NMR) has long been instrumental in the characterization of
intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). This …

Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the
first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract in huntingtin …

Ribonucleoprotein bodies are exemplars of membraneless biomolecular condensates that
can form via spontaneous or driven phase transitions. The fungal protein Whi3 forms …

Huntington's disease (HD) is a neurodegenerative disorder caused by the aggregation of
the mutant huntingtin (mHTT) protein in nerve cells. mHTT self-aggregates to form soluble …

Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

The accumulation of pathogenic protein oligomers and aggregates is associated with
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …

The lack of population-scale databases hampers research and diagnostics for medically
relevant tandem repeats and repeat expansions. We attempt to fill this gap using our …