Fourth generation biofuel from genetically modified algal biomass: Challenges and future directions

H Shokravi, Z Shokravi, M Heidarrezaei, HC Ong… - Chemosphere, 2021 - Elsevier
Genetic engineering applications in the field of biofuel are rapidly expanding due to their
potential to boost biomass productivity while lowering its cost and enhancing its quality …

Next-generation biocontainment systems for engineered organisms

JW Lee, CTY Chan, S Slomovic, JJ Collins - Nature chemical biology, 2018 - nature.com
The increasing use of engineered organisms for industrial, clinical, and environmental
applications poses a growing risk of spreading hazardous biological entities into the …

Safety by design: Biosafety and biosecurity in the age of synthetic genomics

SA Hoffmann, J Diggans, D Densmore, J Dai, T Knight… - Iscience, 2023 - cell.com
Technologies to profoundly engineer biology are becoming increasingly affordable,
powerful, and accessible to a widening group of actors. While offering tremendous potential …

Synthetic addiction extends the productive life time of engineered Escherichia coli populations

P Rugbjerg, K Sarup-Lytzen, M Nagy… - Proceedings of the …, 2018 - National Acad Sciences
Bio-production of chemicals is an important driver of the societal transition toward
sustainability. However, fermentations with heavily engineered production organisms can be …

A genome‐scale yeast library with inducible expression of individual genes

Y Arita, G Kim, Z Li, H Friesen, G Turco… - Molecular Systems …, 2021 - embopress.org
The ability to switch a gene from off to on and monitor dynamic changes provides a powerful
approach for probing gene function and elucidating causal regulatory relationships. Here …

A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid

T Chang, W Ding, S Yan, Y Wang, H Zhang… - Nature …, 2023 - nature.com
Synthetic auxotrophy in which cell viability depends on the presence of an unnatural amino
acid (unAA) provides a powerful strategy to restrict unwanted propagation of genetically …

Biotechnology for secure biocontainment designs in an emerging bioeconomy

KL Arnolds, LR Dahlin, L Ding, C Wu, J Yu… - Current Opinion in …, 2021 - Elsevier
Highlights•Genetically modified organisms are integral to realizing a sustainable
bioeconomy.•Utility of GMOs is dependent on the development of secure biosystems …

Biosensing in smart engineered probiotics

AG Rottinghaus, MB Amrofell, TS Moon - Biotechnology journal, 2020 - Wiley Online Library
Engineered microbes are exciting alternatives to current diagnostics and therapeutics.
Researchers have developed a wide range of genetic tools and parts to engineer probiotic …

Advances in engineering genetic circuits for microbial biocontainment

Y Ma, A Manna, TS Moon - Current Opinion in Systems Biology, 2023 - Elsevier
The development of synthetic biology has resulted in the use of genetically engineered
microbes (GEMs), becoming increasingly critical for addressing global issues such as …

A scalable peptide-GPCR language for engineering multicellular communication

S Billerbeck, J Brisbois, N Agmon, M Jimenez… - Nature …, 2018 - nature.com
Engineering multicellularity is one of the next breakthroughs for Synthetic Biology. A key
bottleneck to building multicellular systems is the lack of a scalable signaling language with …