The C–N cross-coupling chemistry intensely developed since the late 1990s has supplied
synthesists with an overwhelming number of methods to effectively combine carbon and …

Bayesian optimization is a powerful machine learning technique that is particularly well-
suited for optimizing chemical reactions in the early stages of process development. It can …

An in situ-generated complex from [RuCp* Cl2] 2 and dpePhos ligand is reported as an
efficient catalyst in the presence of 5 mol% of LiOtBu for the N-methylation of amines using …

This work demonstrates the dominance of a Ni (0/II/III) cycle for Ni‐photoredox amide
arylation, which contrasts with other Ni‐photoredox C‐heteroatom couplings that operate via …

Although requiring the use of stoichiometric amounts of metal and harsh conditions, the
copper-mediated coupling reactions of aryl halides with amines and phenols (Ullmann …

The arylation of secondary acyclic amides has been achieved with diaryliodonium salts
under mild and metal-free conditions. The methodology has a wide scope, allows synthesis …

We herein developed a reductive transamidation reaction between N-acyl benzotriazoles
(AcBt) and organic nitro compounds or NaNO2 under mild conditions. This protocol …

Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important
transformation in organic synthesis for the construction of pharmaceuticals and fine …

A metal-, base-, and additive-free amide bond formation reaction was developed under an
organic photoredox catalyst. This green approach showed excellent functional selectivity …

CuI-catalyzed coupling of N-acyl-N′-substituted hydrazines with aryl iodides takes place at
60–90° C to afford N-acyl-N′, N′-disubstituted hydrazines regioselectively and thereby …