Wound healing properties of natural products: mechanisms of action

MS Criollo-Mendoza, LA Contreras-Angulo… - Molecules, 2023 - mdpi.com
A wound is the loss of the normal integrity, structure, and functions of the skin due to a
physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex …

Pyrrolizidine alkaloids: chemistry, pharmacology, toxicology and food safety

R Moreira, DM Pereira, P Valentão… - International journal of …, 2018 - mdpi.com
Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently
in species relevant for human consumption. Apart from the toxicity that these molecules can …

[HTML][HTML] Acute and subchronic oral toxicity assessments of Combretum micranthum (Combretaceae) in Wistar rats

M Kpemissi, K Metowogo, M Melila, VP Veerapur… - Toxicology reports, 2020 - Elsevier
Highlights•Acute and subchronic oral toxicity assessments of Combretum micranthum
leaves extract were evaluated in Wistar rats of both sexes.•In acute oral toxicity assessment …

Medicinal plants traditionally used in health care practices by inhabitants of Paddar region of Jammu and Kashmir, India

K Singh, P Kumar, B Kumar, J Sharma… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The present study is the first quantitative assessment of
ethno-medicinal plants of Paddar region of Jammu and Kashmir. Aim of the study The study …

The PERK/eIF2α/ATF4/CHOP pathway plays a role in regulating monocrotaline-induced endoplasmic reticulum stress in rat liver

Y Guo, R Guo, Y Su, J Fu, S Wang, Y Kong… - Research in veterinary …, 2020 - Elsevier
Monocrotaline (MCT) belongs to the category of Pyrrolizdine Alkaloids (PAs), which is one of
important hepatotoxic alkaloid in Crotalaria Lin. Apoptosis is one mechanism of toxic …

Bioactive chemical constituents, in vitro anti-proliferative activity and in vivo toxicity of the extract of Curcuma singularis Gagnep rhizomes

CC Doan, TL Le, NQC Ho, THL La, VC Nguyen… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Curcuma singularis Gagnep is a Vietnamese
medicinal plant which has been commonly used as a medicinal remedy in traditional and …

Ethnopharmacological survey, mineral and chemical content, in vitro antioxidant, and antibacterial activities of aqueous and organic extracts of Chamaerops humilis L …

N Lachkar, F Lamchouri, H Toufik - BioMed Research …, 2022 - Wiley Online Library
Introduction. The present study is carried out for the first time on Chamaerops humilis L. var.
argentea Andre from the region of Taza using an ethnopharmacological survey, an …

Evaluation of in vitro cytotoxicity and in vivo potential toxicity of the extract from in vitro cultivated Anoectochilus roxburghii Lindl

DC Chung, T Long Le, NQC Ho… - Journal of Toxicology …, 2021 - Taylor & Francis
Anoectochilus roxburghii Lind.(A. roxburghii) has promising anti-oxidant, hyperglycemic,
hepatoprotective, and immunomodulatory activities as well as anti-tumor effects. However …

CHOP regulates endoplasmic reticulum stress-mediated hepatoxicity induced by monocrotaline

Y Guo, C Yang, R Guo, R Huang, Y Su… - Frontiers in …, 2021 - frontiersin.org
Monocrotaline (MCT), a pyrrolizidine alkaloid, is the major toxin in Crotalaria, which causes
cell apoptosis in humans and animals. It has been reported that the liver is a vulnerable …

[HTML][HTML] Cytotoxic activity of cis-(E)-and trans-(Z)-spiroethers isolated from various Arnebia species

SF Taghizadeh, M Azizi, R Rezaee… - South African Journal of …, 2021 - Elsevier
Spiroethers comprise a sub-class of spirocycles and exert various biological properties such
as antibacterial and anti-tumor activities. The present study investigated the total spiroether …