Progress in antimelanoma research of natural triterpenoids and their derivatives: mechanisms of action, bioavailability enhancement and structure modifications

M Grudzińska, B Stachnik, A Galanty, A Sołtys… - Molecules, 2023 - mdpi.com
Melanoma is one of the most dangerous forms of skin cancer, characterized by early
metastasis and rapid development. In search for effective treatment options, much attention …

Anti-angiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in Balb/c mice

CA Dehelean, S Feflea, D Gheorgheosu… - Journal of …, 2013 - ingentaconnect.com
Betulin (Bet), the main component of birch tree bark, has been recently reported to exert
anticancer activity in several cell lines; however the underlying mechanisms are only …

Influence of PVA molecular weight and concentration on electrospinnability of birch bark extract-loaded nanofibrous scaffolds intended for enhanced wound healing

FK Mwiiri, R Daniels - Molecules, 2020 - mdpi.com
Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects
including enhanced wound healing. Apart from an already authorized oleogel, electrospun …

Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

C Şoica, C Dehelean, C Danciu, HM Wang… - International Journal of …, 2012 - mdpi.com
Given the present high incidence of melanoma and skin cancer, interest in potential drugs of
plant origin has increased significantly. Pentacyclic lupane-type triterpenes are widely …

New improved drug delivery technologies for pentacyclic triterpenes: A review

C Soica, C Trandafirescu, C Danciu… - Protein and Peptide …, 2014 - ingentaconnect.com
Phytochemicals are becoming more and more interesting in the field of therapeutic research,
mainly in the treatment of chronic illnesses, due to the fact that many synthetic drugs cause …

Electrospun bioactive wound dressing containing colloidal dispersions of birch bark dry extract

FK Mwiiri, JM Brandner, R Daniels - Pharmaceutics, 2020 - mdpi.com
Novel birch bark dry extract (TE)-loaded polyvinyl alcohol (PVA) fiber mats intended for
wound therapy were developed through an electrospinning process. Colloidal dispersions …

Betulin as an Antitumor Agent Tested in vitro on A431, HeLa and MCF7, and as an Angiogenic Inhibitor in vivo in the CAM Assay

CA Dehelean, S Feflea, J Molnár… - Natural product …, 2012 - journals.sagepub.com
Betulin, an important compound found in birch tree bark, can be converted to betulinic acid,
an important pharmacological substance. Betulin has recently been reported as a cytotoxic …

Extended investigation of Ficus religiosa based PVA electrospun nanofiber for cosmeceutical application

K Mishra, S Sinha - Materials Today: Proceedings, 2023 - Elsevier
The compositional characteristics, antibacterial, and antioxidant activity of polyvinyl alcohol
(PVA) containing Ficus religiosa leaf extract (FR) at 5% and 10 wt% fabricated through …

Molecular conformation changes along the malignancy revealed by optical nanosensors

S Cinta Pinzaru, A Falamas… - Journal of Cellular and …, 2013 - Wiley Online Library
An interdisciplinary approach employing functionalized nanoparticles and ultrasensitive
spectroscopic techniques is reported here to track the molecular changes in early stage of …

Optimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer

FK Mwiiri, R Daniels - Pharmaceutics, 2020 - mdpi.com
This study investigated the formulation and processing of aqueous colloidal dispersions
containing a birch bark dry extract (TE) as the active substance and hydrogenated …