X Liang, L Zhang, SK Natarajan… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: The imino acid proline is utilized by different organisms to offset cellular imbalances caused by environmental stress. The wide use in nature of proline as a stress …
PS Romero-Perez, Y Dorone, E Flores… - Chemical …, 2023 - ACS Publications
The molecular machinery that enables life has evolved in water, yet many of the organisms around us are able to survive even extreme desiccation. Especially remarkable are single …
Highlights•Liquid-liquid phase separation underlies the formation of membraneless organelles within cells.•Theory and molecular simulations help to relate interactions at the …
CJ Roberts - Trends in biotechnology, 2014 - cell.com
Although it is well known that proteins are only marginally stable in their folded states, it is often less well appreciated that most proteins are inherently aggregation-prone in their …
DR Canchi, AE García - Annual review of physical chemistry, 2013 - annualreviews.org
Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous solution can easily be altered by the addition of small organic molecules known as …
NK Jain, I Roy - Protein Science, 2009 - Wiley Online Library
Trehalose is a ubiquitous molecule that occurs in lower and higher life forms but not in mammals. Till about 40 years ago, trehalose was visualized as a storage molecule, aiding …
TO Street, DW Bolen, GD Rose - Proceedings of the …, 2006 - National Acad Sciences
Osmolytes are small organic compounds that affect protein stability and are ubiquitous in living systems. In the equilibrium protein folding reaction, unfolded (U)⇌ native (N) …
Y Zhang, PS Cremer - Annual review of physical chemistry, 2010 - annualreviews.org
The study of the interactions of salts and osmolytes with macromolecules in aqueous solution originated with experiments concerning protein precipitation more than 100 years …
S Ausaf Ali, I Hassan, A Islam… - Current Protein and …, 2014 - ingentaconnect.com
Solvent accessible surface area (SASA) of proteins has always been considered as a decisive factor in protein folding and stability studies. It is defined as the surface …