Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …

Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity.
Olfactory dysfunction manifests early in several neurodegenerative disorders including …

Introduction: Alzheimer's disease (AD) is a major cause of the development of cognitive
decline and dementia. AD and associated dementias (ADRD) are the major contributors to …

Noise is a basic ingredient in data, since observed data are always contaminated by
unwanted deviations, ie, noise, which, in the case of overdetermined systems (with more …

In our recent transcriptomic meta-analysis, we used random forest machine learning to
accurately predict age in human blood, bone, brain, heart, and retina tissues given gene …

Alzheimer's disease is a very complex disease and better explanations and models are
needed to understand how neurons are affected and microglia are activated. A new model …

Alzheimer's disease (AD) is a severe neurodegenerative disease for which there is currently
no effective treatment. Mild cognitive impairment (MCI) is an early disease that may progress …

Background: Single Amino Acid Polymorphisms (SAPs) or nonsynonymous Single
Nucleotide Variants (nsSNVs) are the most common genetic variations. They result from …

Abstract Human Single Amino Acid Polymorphisms (SAPs) or Single Amino Acid Variants
(SAVs) usually named as nonsynonymous Single Nucleotide Variants nsSNVs) represent …

Genome-wide association studies (GWAS) are powerful tools for identifying genetic variants
associated with complex diseases. However, their utility is limited in elucidating the genetics …