CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins
D Couvin, A Bernheim, C Toffano-Nioche… - Nucleic acids …, 2018 - academic.oup.com
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against …
associated (Cas) proteins confer bacteria and archaea adaptive immunity against …
CRISPR-Cas bioinformatics
OS Alkhnbashi, T Meier, A Mitrofanov, R Backofen… - Methods, 2020 - Elsevier
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated
proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes …
proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes …
Systematic discovery of natural CRISPR-Cas12a inhibitors
Cas12a (Cpf1) is a CRISPR-associated nuclease with broad utility for synthetic genome
engineering, agricultural genomics, and biomedical applications. Although bacteria …
engineering, agricultural genomics, and biomedical applications. Although bacteria …
CRISPRCasdb a successor of CRISPRdb containing CRISPR arrays and cas genes from complete genome sequences, and tools to download and query lists of …
Abstract In Archaea and Bacteria, the arrays called CRISPRs for 'clustered regularly
interspaced short palindromic repeats' and the CRISPR associated genes or cas provide …
interspaced short palindromic repeats' and the CRISPR associated genes or cas provide …
The immune system of prokaryotes: potential applications and implications for gene editing
S Liu, H Liu, X Wang, L Shi - Biotechnology Journal, 2024 - Wiley Online Library
Gene therapy has revolutionized the treatment of genetic diseases. Spearheading this
revolution are sophisticated genome editing methods such as TALENs, ZFNs, and CRISPR …
revolution are sophisticated genome editing methods such as TALENs, ZFNs, and CRISPR …
Transcriptional recording by CRISPR spacer acquisition from RNA
F Schmidt, MY Cherepkova, RJ Platt - Nature, 2018 - nature.com
The ability to record transcriptional events within a cell over time would help to elucidate
how molecular events give rise to complex cellular behaviours and states. However, current …
how molecular events give rise to complex cellular behaviours and states. However, current …
CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
R Pinilla-Redondo, J Russel… - Nucleic acids …, 2022 - academic.oup.com
Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
CRISPRidentify: identification of CRISPR arrays using machine learning approach
A Mitrofanov, OS Alkhnbashi, SA Shmakov… - Nucleic acids …, 2021 - academic.oup.com
CRISPR–Cas are adaptive immune systems that degrade foreign genetic elements in
archaea and bacteria. In carrying out their immune functions, CRISPR–Cas systems heavily …
archaea and bacteria. In carrying out their immune functions, CRISPR–Cas systems heavily …
Roles of bacteriophages, plasmids and CRISPR immunity in microbial community dynamics revealed using time-series integrated meta-omics
Viruses and plasmids (invasive mobile genetic elements (iMGEs)) have important roles in
shaping microbial communities, but their dynamic interactions with CRISPR-based immunity …
shaping microbial communities, but their dynamic interactions with CRISPR-based immunity …