Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age
and has become increasingly more common with advances in age. The number of …

A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more
acceptance, but the underlying mechanisms through which it participates in …

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra,
resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial …

Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

J. Neurochem.(2011) 118, 939–957. Abstract Alterations of iron levels in the brain has been
observed and documented in a number of neurodegenerative disorders including …

Growing evidence highlights a role for mitochondrial dysfunction and oxidative stress as
underlying contributors to Parkinson's disease (PD) pathogenesis. DJ-1 (PARK7) is a …

DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has
homologs in nearly all organisms. Because of its connection to parkinsonism and cancer …