Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Terpenes as bacterial efflux pump inhibitors: A systematic review

KJSDO Dias, GM Miranda, JR Bessa… - Frontiers in …, 2022 - frontiersin.org
Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

In vitro and in silico evidences about the inhibition of MepA efflux pump by coumarin derivatives

ALAR Martin, RLS Pereira, JE Rocha, PAM Farias… - Microbial …, 2023 - Elsevier
The discovery of antibiotics has significantly transformed the outcomes of bacterial infections
in the last decades. However, the development of antibiotic resistance mechanisms has …

Antibacterial effect and evaluation of the inhibitory effect against efflux pump in Staphylococcus aureus by abietic acid: In vitro and in silico assays

MG de Lima Silva, LYS da Silva, TS de Freitas… - Process …, 2022 - Elsevier
Abietic acid is a diterpene found in resins mainly from diverse species of genus Pinus. The
present study evaluated the antibacterial and inhibitory effect against the NorA and MepA …

Antimicrobial resistance expansion in pathogens: a review of current mitigation strategies and advances towards innovative therapy

MA Adefisoye, AO Olaniran - JAC-Antimicrobial Resistance, 2023 - academic.oup.com
The escalating problem of antimicrobial resistance (AMR) proliferation in clinically important
pathogens has become one of the biggest threats to human health and the global economy …

Mechanism of antibacterial phytoconstituents: An updated review

S Abass, R Parveen, M Irfan, Z Malik, SA Husain… - Archives of …, 2024 - Springer
The increase of multiple drug resistance bacteria significantly diminishes the effectiveness of
antibiotic armory and subsequently exaggerates the level of therapeutic failure …

Antibacterial, bacteriolytic, antibiofilm, and synergistic effects of the peel oils of Citrus microcarpa and Citrus x amblycarpa with tetracycline against foodborne …

AW Septama, Y Yuandani… - Letters in Applied …, 2023 - academic.oup.com
Citrus essential oils (EOs) have shown significant antibacterial activity. The present study
was undertaken to evaluate the antibacterial activity of the peel oils of Citrus microcarpa and …

[HTML][HTML] Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration

PR Freitas, ACJ de Araújo, IM Araújo… - Biomedicine & …, 2024 - Elsevier
Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the
efflux system is widely studied among the resistance mechanisms developed by this …

An efficient approach for separating essential oil and polysaccharides simultaneously from fresh leaves of guajava by microwave-mediated hydrodistillation with …

X Zhang, Y Huang, L Zhang, H Zhu, Y Niu, Y An, Z Liu - Separations, 2022 - mdpi.com
The essential oils and polysaccharides from guava leaves have important functions. In the
process of microwave extraction of plant essential oils and polysaccharides, pretreatment …

Chemical profiles and antibacterial actions of Zanthoxylum acanthopodium DC. Essential oil growing in Indonesia

AW Septama, EP Rahmi, AN Tasfiyati, NA Khairunnisa… - Fitoterapia, 2025 - Elsevier
Foodborne illness caused by pathogens has been a major health problem. Antibacterial
resistance renders therapeutic options for treating the condition more limited, hence there is …