Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The relationship of alpha-synuclein to mitochondrial dynamics and quality control

NJ Thorne, DA Tumbarello - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …

[HTML][HTML] Nanomotor-based H2S donor with mitochondrial targeting function for treatment of Parkinson's disease

Z Zhao, L Chen, C Yang, W Guo, Y Huang, W Wang… - Bioactive Materials, 2024 - Elsevier
Reduction of endogenous hydrogen sulfide (H 2 S) is considered to have an important
impact on the progress of Parkinson's disease (PD), thus exogenous H 2 S supplementation …

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

X Hou, THY Chen, S Koga, JM Bredenberg… - Brain …, 2023 - Wiley Online Library
Alpha‐synuclein (αsyn) aggregates are pathological features of several neurodegenerative
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …

The Role of Ubiquitin–Proteasome System and Mitophagy in the Pathogenesis of Parkinson's Disease

Y Liang, G Zhong, M Ren, T Sun, Y Li, M Ye… - NeuroMolecular …, 2023 - Springer
Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

[HTML][HTML] Mitochondrial signaling on innate immunity activation in Parkinson disease

JD Magalhães, SM Cardoso - Current Opinion in Neurobiology, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by the
accumulation of alpha-synuclein (aSyn) in the nigrostriatal pathway that is followed by …

Liquid–liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson's disease pathogenesis

ED Ruiz-Ortega, A Wilkaniec… - Frontiers in Molecular …, 2024 - frontiersin.org
Parkinson's disease (PD) and other synucleinopathies are characterized by the aggregation
and deposition of alpha-synuclein (α-syn) in brain cells, forming insoluble inclusions such as …

[HTML][HTML] Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease

C Peggion, L Barazzuol, E Poggio, T Calì, M Brini - Cell Calcium, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease caused by multifactorial
pathogenic mechanisms. Familial PD is linked with genetic mutations in genes whose …

Single image capture of bioactive ion crosstalk within inter‐organelle membrane contacts at nanometer resolution

G Fang, H Chen, X Shao, H Wang, D Zhan… - Small …, 2022 - Wiley Online Library
Rapid bioactive ion exchange is a form of communication that regulates a wide range of
biological processes. Despite advances in super‐resolution optical microscopy, visualizing …

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's disease

S Narwal, A Singh, M Tare - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
One of the hallmarks of Parkinson's Disease (PD) is aggregation of incorrectly folded α-
synuclein (SNCA) protein resulting in selective death of dopaminergic neurons. Another …