Tumor growth and progression are strictly dependent on the adequate blood supply of
oxygen and nutrients. The formation of new blood vessels and vascular networks is …

Highlights•MIPs are artificial receptors designed to target specific molecules.•MIPs showed
enhanced drug loading and targeted delivery.•MIPs showed sustained and controlled …

Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune
evasion. Previous studies evaluated ITH mostly based on DNA alterations. Here, we …

Angiogenesis is a hallmark of cancer biology, and neoadjuvant therapies targeting either
tumor vasculature or VEGF signaling have been developed to treat solid malignant tumors …

Cancer stemness is associated with high malignancy and low differentiation, as well as
therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC) …

Purpose Development of chemoresistance is one of the major obstacles to the treatment of
head and neck squamous cell carcinoma (HNSCC). The PI3K/Akt pathway, involved in drug …

In recent years, there has been an increasing interest in the study of Ag (I) coordination
compounds as potent antibacterial and anticancer agents. Herein, a series of Ag (I) …

Purpose: Fibroblast growth factor 10 (FGF10) is involved in eye, meibomian, and lacrimal
gland (LG) development, but its function in adult eye structures remains unknown. This study …

Hypoxia is an important cause of cervical lymph nodes metastasis and recurrence of thyroid
cancer, but its specific mechanism remains unclear. In the present study, we constructed a …

Osteosarcoma (OS) is the most common high-grade malignant bone tumor in teenagers.
MicroRNAs can function as posttranscriptional regulators of gene expression, playing critical …