Wnt/β-catenin signaling is a branch of a functional network that dates back to the first
metazoans and it is involved in a broad range of biological systems including stem cells …

Several cellular signaling pathways are regulated by ADP-ribosylation, a posttranslational
modification catalyzed by members of the ARTD superfamily. Tankyrases are …

The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-
subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many …

The Wnt/β-catenin signalling pathway plays essential roles in embryonic development and
adult tissue homeostasis, and deregulation of this pathway has been linked to cancer. Axin …

Protein poly (ADP-ribosyl) ation (PARylation) has a role in diverse cellular processes such
as DNA repair, transcription, Wnt signalling, and cell death,,,,,. Recent studies have shown …

Tankyrase 1 and tankyrase 2 are poly (ADP‐ribosyl) ases that are distinguishable from other
members of the enzyme family by the structural features of the catalytic domain, and the …

Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which
is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for …

Abstract Background The Poly (ADP-ribose) polymerase (PARP) superfamily was originally
identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins …

Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Background New pharmacologic targets are urgently needed to treat or prevent lung cancer,
the most common cause of cancer death for men and women. This study identified one such …