Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Obesity is highly prevalent, and its incidence is increasing. The previous study showing a
major effect of paternal obesity on metabolic health of offspring is confounded by …

The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having
no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) …

MicroRNAs are small non‐coding RNA guide molecules that regulate gene expression via
association with effector complexes and sequence‐specific recognition of target sites on …

Although it is believed that mammalian sperm carry small noncoding RNAs (sncRNAs) into
oocytes during fertilization, it remains unknown whether these sperm-borne sncRNAs truly …

Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …