Hybrid drugs—a strategy for overcoming anticancer drug resistance?
M Szumilak, A Wiktorowska-Owczarek, A Stanczak - Molecules, 2021 - mdpi.com
Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …
The potential of combi-molecules with DNA-damaging function as anticancer agents
G Sun, T Fan, L Zhao, Y Zhou… - Future medicinal …, 2017 - Taylor & Francis
DNA-damaging agents, such as methylating agents, chloroethylating agents and platinum-
based agents, have been extensively used as anticancer drugs. However, the side effects …
based agents, have been extensively used as anticancer drugs. However, the side effects …
Metal-free direct hydrosulfonylation of azodicarboxylates with sulfinic acids leading to sulfonylhydrazine derivatives
J Wen, W Wei, D Yang, Y Fan, L Fu… - Synthetic …, 2015 - Taylor & Francis
A metal-free direct hydrosulfonylation protocol of azodicarboxylates with sulfinic acids has
been developed for the construction of sulfonylhydrazine-1, 2-dicarboxylates at room …
been developed for the construction of sulfonylhydrazine-1, 2-dicarboxylates at room …
Antitumor sulfonylhydrazines: Design, structure–activity relationships, resistance mechanisms, and strategies for improving therapeutic utility
K Shyam, PG Penketh, RP Baumann… - Journal of Medicinal …, 2015 - ACS Publications
1, 2-Bis (sulfonyl)-1-alkylhydrazines (BSHs) were conceived as more specific DNA guanine
O-6 methylating and chloroethylating agents lacking many of the undesirable toxicophores …
O-6 methylating and chloroethylating agents lacking many of the undesirable toxicophores …
Physicochemical considerations of tumor selective drug delivery and activity confinement with particular reference to 1, 2-bis (sulfonyl)-1-alkylhydrazines delivery
P Penketh, H Williamson, K Shyam - Current Drug Delivery, 2020 - ingentaconnect.com
Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence
frequently causes disease recurrence and death. Here, we described the physicochemical …
frequently causes disease recurrence and death. Here, we described the physicochemical …
Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in …
L Li, S Li, G Sun, R Peng, L Zhao, R Zhong - PLoS One, 2015 - journals.plos.org
Chloroethylnitrosoureas (CENUs), which are bifunctional alkylating agents widely used in
the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a …
the clinical treatment of cancer, exert anticancer activity by inducing crosslink within a …