Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Current status of the diagnosis and management of osteoporosis

A Aibar-Almazán, A Voltes-Martínez… - International journal of …, 2022 - mdpi.com
Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Bone tissue engineering scaffolds: function of multi‐material hierarchically structured scaffolds

TM Koushik, CM Miller… - Advanced healthcare …, 2023 - Wiley Online Library
Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in
materials, processing techniques, and the understanding of bone healing pathways have …

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Regulation and role of transcription factors in osteogenesis

WCW Chan, Z Tan, MKT To, D Chan - International journal of molecular …, 2021 - mdpi.com
Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Skeletal aging and osteoporosis: mechanisms and therapeutics

A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Topography-mediated immunomodulation in osseointegration; Ally or Enemy

S Shirazi, S Ravindran, LF Cooper - Biomaterials, 2022 - Elsevier
Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

Antioxidant, anti-inflammatory, anti-menopausal, and anti-cancer effects of lignans and their metabolites

WY Jang, MY Kim, JY Cho - International journal of molecular sciences, 2022 - mdpi.com
Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer,
there is a high demand for effective methods to modulate inflammatory responses. Among …

Phylogenomic analyses provide insights into primate evolution

Y Shao, L Zhou, F Li, L Zhao, BL Zhang, F Shao… - Science, 2023 - science.org
Comparative analysis of primate genomes within a phylogenetic context is essential for
understanding the evolution of human genetic architecture and primate diversity. We present …

Bone aging, cellular senescence, and osteoporosis

RJ Pignolo, SF Law, A Chandra - Journal of Bone and Mineral …, 2021 - academic.oup.com
Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …