With a political debate about the potential risks and benefits of cannabis use as a backdrop,
the wave of legalization and liberalization initiatives continues to spread. Four states …

Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Importance Animal studies have shown that the adolescent brain is sensitive to disruptions
in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral …

Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …

The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

Epidemiological evidence demonstrates that cannabis use is associated with an increased
risk of psychotic outcomes, and confirms a dose‐response relationship between the level of …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …

Cannabis use is observationally associated with an increased risk of schizophrenia, but
whether the relationship is causal is not known. Using a genetic approach, we took 10 …

Schizophrenia is a heritable complex phenotype associated with a background risk
involving multiple common genetic variants of small effect and a multitude of environmental …