Gout is a picturesque presentation of uric acid disturbance. It is the most well understood
and described type of arthritis. Its epidemiology is studied. New insights into the …

Researchers have recently made advances in defining the pathogenesis of gout, including
elucidating its risk factors and tracing the molecular mechanisms of renal urate transport and …

Abstract Interleukin (IL)-8, a prototypic human chemokine, was detected more than a decade
ago as the founding member of the chemokine superfamily. One of the most remarkable …

Angiogenesis and inflammation are closely integrated processes in osteoarthritis (OA) and
may affect disease progression and pain. Inflammation can stimulate angiogenesis, and …

Table of contents: I. Structure and function of joints, connective tissue, and muscle. II.
Immune and inflammatory responses. III. Evaluation of the patient. IV. Special issues of the …

Objective In gout, incompletely defined molecular factors alter recognition of dormant
articular and bursal monosodium urate monohydrate (MSU) crystal deposits, thereby …

2009-02-04 Assigned to ARRAY BIOPHARMA, INC. reassignment ARRAY BIOPHARMA,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

Calcium oxalate (CaOx), calcium phosphate (CaP), and uric acid or urate are the most
common crystals seen in the kidneys. Most of the crystals evoke an inflammatory response …

Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-
wide association studies (GWASs) of gout have been reported, they included self-reported …

Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU)
deposited in synovium and articular cartilage initiate joint inflammation and cartilage …