T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

The endoplasmic reticulum (ER) is the major folding compartment for secreted and
membrane proteins and is the site of a specific chaperone system, the calnexin cycle, for …

Recognition and elimination of virally or malignantly transformed cells are pivotal tasks of
the adaptive immune system. For efficient immune detection, snapshots of the cellular …

Glycans and glycan-binding proteins are central to a properly functioning immune system.
Perhaps the best known example of this is the selectin family of surface proteins that are …

Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse
array of antigens and themselves being recognized by a broad array of receptors. The …

In order to maintain proper cellular functions, all living cells, from bacteria to mammalian
cells, must carry out a rigorous quality control process in which nascent and newly …

Essentially all cells are covered with a dense coat of different glycan structures/sugar chains,
giving rise to the so‐called glycocalyx. Changes in cellular glycosylation are a hallmark of …

In a complex multicellular organism, different cell types engage in specialist functions, and
as a result, the secretory output of cells and tissues varies widely. Whereas some quiescent …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …

Abstract MHC class I (MHC-I) molecules present a blueprint of the intracellular proteome to T
cells allowing them to control infection or malignant transformation. As a response …