Leishmania and the leishmaniases: a parasite genetic update and advances in taxonomy, epidemiology and pathogenicity in humans

AL Bañuls, M Hide, F Prugnolle - Advances in parasitology, 2007 - Elsevier
Leishmaniases remain a major public health problem today despite the vast amount of
research conducted on Leishmania pathogens. The biological model is genetically and …

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design

F Lecaille, J Kaleta, D Brömme - Chemical reviews, 2002 - ACS Publications
Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Second-generation vaccines against leishmaniasis

RN Coler, SG Reed - Trends in parasitology, 2005 - cell.com
Several species of Leishmania cause human diseases that range from self-healing
cutaneous lesions to fatal visceral leishmaniasis, mucosal leishmaniasis and diffuse …

Vaccine candidates for leishmaniasis: a review

R Nagill, S Kaur - International immunopharmacology, 2011 - Elsevier
Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …

Leishmania vaccines: progress and problems

L Kedzierski, Y Zhu, E Handman - Parasitology, 2006 - cambridge.org
Leishmania are protozoan parasites spread by a sandfly insect vector and causing a
spectrum of diseases collectively known as leishmaniasis. The disease is a significant …

Experimental Validation of Multi-Epitope Peptides Including Promising MHC Class I- and II-Restricted Epitopes of Four Known Leishmania infantum Proteins

M Agallou, E Athanasiou, O Koutsoni… - Frontiers in …, 2014 - frontiersin.org
Leishmaniasis is a significant worldwide health problem for which no vaccine exists.
Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity …

Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II …

S Rafati, A Nakhaee, T Taheri, Y Taslimi, H Darabi… - Vaccine, 2005 - Elsevier
Leishmania infantum is known to be associated with visceral leishmaniasis in Iran and
canids are natural reservoirs. Control of disease in dogs appears to be one of the most …

Host gender in parasitic infections of mammals: an evaluation of the female host supremacy paradigm

J Morales-Montor, A Chavarria… - Journal of …, 2004 - meridian.allenpress.com
A review of current literature on mammalian hosts' sexual dimorphism (SD) in parasitic
infections revealed that (1) it is a scarcely and superficially studied biological phenomenon …

A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major

S Rafati, AH Salmanian, T Taheri, M Vafa, N Fasel - Vaccine, 2001 - Elsevier
The protection elicited by the intramuscular injection of two plasmid DNAs encoding
Leishmania major cysteine proteinase type I (CPb) and type II (CPa) was evaluated in a …

Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory‐secretory products of Clonorchis sinensis adult worms

JW Ju, HN Joo, MR Lee, SH Cho, HI Cheun… - …, 2009 - Wiley Online Library
Clonorchis sinensis, the Chinese liver fluke, is the causative agent of clonorchiasis as well
as liver and biliary diseases. The excretory‐secretory products (ESPs) of the parasites play …