Chemistry and biology of mammalian metallothioneins

M Vašák, G Meloni - JBIC Journal of Biological Inorganic Chemistry, 2011 - Springer
Metallothioneins (MTs) are a class of ubiquitously occurring low molecular mass, cysteine-
and metal-rich proteins containing sulfur-based metal clusters formed with Zn (II), Cd (II), and …

Diversity and distribution of plant metallothioneins: a review of structure, properties and functions

OI Leszczyszyn, HT Imam, CA Blindauer - Metallomics, 2013 - academic.oup.com
More than 30 years have passed since the discovery of the first plant metallothionein in
wheat embryos, from which the emergence of a uniquely diverse metallothionein family with …

Lipid geometrical isomerism: from chemistry to biology and diagnostics

C Chatgilialoglu, C Ferreri, M Melchiorre… - Chemical …, 2014 - ACS Publications
Lipid research in the life sciences has renewed its attractiveness in the last two decades or
so, going from chemical, analytical, and biological subjects, to making important connections …

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more

CA Blindauer, OI Leszczyszyn - Natural product reports, 2010 - pubs.rsc.org
Covering: 1999 to 2009 Metallothioneins have been the subject of intense study for five
decades, and have greatly inspired the development of bio-analytical methodologies …

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence

C Ding, RA Festa, YL Chen, A Espart, Ò Palacios… - Cell host & …, 2013 - cell.com
Copper (Cu) is an essential metal that is toxic at high concentrations. Thus, pathogens often
rely on host Cu for growth, but host cells can hyperaccumulate Cu to exert antimicrobial …

Copper metallothioneins

J Calvo, H Jung, G Meloni - Iubmb Life, 2017 - Wiley Online Library
Metallothioneins (MTs) are a class of low molecular weight and cysteine‐rich metal binding
proteins present in all the branches of the tree of life. MTs efficiently bind with high affinity …

State-of-the-art of metallothioneins at the beginning of the 21st century

M Capdevila, R Bofill, O Palacios, S Atrian - Coordination Chemistry …, 2012 - Elsevier
Metallothioneins (MTs) are a particular type of small metalloprotein that possess a significant
amount of Cys residues, which confer upon them an extraordinary capacity for heavy metal …

Redox biochemistry of mammalian metallothioneins

W Maret - JBIC Journal of Biological Inorganic Chemistry, 2011 - Springer
Metallothionein (MT) is a generic name for certain families of structurally rather variable
metal-binding proteins. While purely chemical or biological approaches failed to establish a …

Zn-and Cu-thioneins: a functional classification for metallothioneins?

Ò Palacios, S Atrian, M Capdevila - JBIC Journal of Biological Inorganic …, 2011 - Springer
This report intends to provide the reader with a deeper insight in the chemical, and
extensively biological, characteristics of the metallothionein (MT) system. We have devoted …

Advances in the molecular understanding of biological zinc transport

CA Blindauer - Chemical Communications, 2015 - pubs.rsc.org
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for
function, and hence zinc is essential for almost any given metabolic process. It is therefore of …