The conformational restriction (rigidification) of a flexible ligand has often been a commonly
used strategy in drug design, as it can minimize the entropic loss associated with the ligand …

The cyclopentane carbocyclic ring system, while ubiquitous in nature, is not usually
considered a privileged core structure for the development of a drug candidate due, in part …

New radical-triggered three-component bicyclization cascades of 2-alkynyl aryldiazonium
tetrafluoroborates with a sulfur dioxide surrogate DABCO·(SO2) 2 and internal alkynes such …

A new photocatalytic three-component annulation of 2-alkynylaryldiazonium
tetrafluoroborates with γ-hydroxyl terminal alkynes and sodium metabisulfite is reported …

Chiral sulfones, a class of organic compounds with broad application prospects in organic
synthesis and pharmaceutical chemistry, are an important part of building bioactive …

The human neuraminidase enzymes (hNEU) are a family of four isoenzymes that hydrolyze
sialosides, including gangliosides and glycoproteins. These enzymes are proposed to play …

The diverse substitution patterns available to 3-sulfolenes have long made them useful for
the preparation of multi-substituted 1, 3-diene equivalents. More recently, the 3-sulfolene …

We present herein an efficient and practical method for a gram scale synthesis of 3-
sulfolenes using sodium metabisulfite as a safe, inexpensive, and easy to handle sulfur …

An asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates and β-keto sulfones
was investigated by the catalysis of modified cinchona alkaloids, whose products underwent …

Synthesis of 3-aryl-6a-methyl-6-nitro-1-phenylhexahydrothieno[2,3-d]pyrazole 4,4-dioxides
Page 1 Mendeleev Commun., 2015, 25, 191–192 – 191 – Mendeleev Communications © 2015 …