Patients with severe infections almost invariably exhibit evidence of activation of the
coagulation system. The lungs are amongst the most frequently affected organs during …

Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a …

Objective: High mobility group box 1 (HMGB1) has been implicated as a late mediator in
sepsis. We here sought to determine the extent of HMGB1 release in patients with sepsis …

High-mobility group box (HMGB) 1 is a recently discovered proinflammatory mediator that
contributes to acute lung injury. We determined HMGB-1 levels in bronchoalveolar lavage …

Background Systemic blockade of tissue factor (TF) attenuates acute lung injury (ALI) in
animal models of sepsis but the effects of global TF deficiency are unknown. We used mice …

Objective Use of lung-protective mechanical ventilation (MV) by applying lower tidal
volumes is recommended in patients suffering from acute lung injury (ALI) or acute …

Acute inflammatory events, such as those that occur in sepsis, lead to dysregulation of the
coagulation cascade. The hemostatic imbalance in sepsis, characterized by the excessive …

ABSTRACT S100A12 is highly expressed, and serum levels correlate with individual
disease activity in patients with inflammatory diseases. We here sought to determine the …

Background: Pulmonary coagulopathy may contribute to an adverse outcome in lung injury.
We assessed the effects of local anticoagulant therapy on bronchoalveolar and systemic …

Introduction 3. Tissue Factor and Coagulation 4. Tissue Factor and Protease Activated
Receptors 5. Tissue Factor and Development 6. Tissue Factor and Pregnancy 7. Tissue …