Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies.
Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas …

Objectives Secondary antibody deficiency (SAD), associated with severe, recurrent or
persistent infections, is common in patients with haematological malignancies (HM), but …

Lymphoid hematologic malignancies (HMs) and their treatment may result in secondary
antibody deficiency (SAD), which is associated with an increased risk and susceptibility for …

Objective To review selected published studies related to the diagnostic evaluation of
antibody deficiency. Data Sources Published literature. Study Selections Studies related to …

Inborn errors of immunity (IEIs) or primary immunodeficiency diseases, are disorders caused
by genetic defects affecting immune function. Clinically, IEI presents mainly as recurrent or …

Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent
infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to …

The goal of vaccination (or immunization) is to prevent disease by the intentional exposure
of a host to an infectious agent or to some of its components. Via the induction of …

Response to polysaccharide vaccination can be an invaluable tool for assessing
functionality of the adaptive immune system. Measurement of antibodies raised in response …

Common variable immunodeficiency (CVID) is the most common clinically significant
primary antibody deficiency diagnosed in adults. The early symptoms are not specific. They …

An increasing healthcare challenge in the management of haematological malignancy (HM)
is secondary immunodeficiency. From January 2019, the EMA included the evaluation of …