Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …

Rationale: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic
(PK) modelling approaches are widely accepted in non-radiopharmaceutical drug …

Across multiple sectors, including food, cosmetics and pharmaceutical industries, there is a
need to predict the potential effects of xenobiotics. These effects are determined by the …

The microbiome is known to regulate many aspects of host health and disease and is
increasingly being recognized as a key mediator of drug action. However, investigating the …

The non–vitamin K antagonist oral anticoagulant rivaroxaban is used in several
thromboembolic disorders. Rivaroxaban is eliminated via both metabolic degradation and …

The application of physiologically based pharmacokinetic models to nanoparticles is still
very restricted and challenging, owing to the complicated in vivo transport mechanisms …

Precision medicine is an emerging paradigm that aims at maximizing the benefits and
minimizing the adverse effects of drugs. Realistic mechanistic models are needed to …

Background Exclusive breastfeeding of infants under 6 months of age is recommended by
the World Health Organization. In 2021, over 300 million combined incident cases of …

The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug
pharmacokinetics (PK) by combining changes in blood flow and pathophysiological …

Objectives In this review, the current biopharmaceutical approaches for evaluation of oral
formulation performance in paediatrics are discussed. Key findings The paediatric …