Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are toxic, non-
proteinogenic amino acids formed by post-translational modification and are uremic toxins …

Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

The signaling adaptor MAVS forms prion-like aggregates to activate the innate antiviral
immune response after viral infection. However, spontaneous aggregation of MAVS can …

Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that
catalyzes the formation of symmetric dimethylarginine in a number of nuclear and …

Epigenetic modifications play important roles during the pathogenesis of multiple myeloma
(MM). Herein, we found that protein arginine methyltransferase 1 (PRMT1) was highly …

Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

Protein arginine methyltransferases (PRMTs) catalyze the methyl transfer to the arginine
residues of protein substrates and are classified into three major types based on the final …

PRMT1, the major protein arginine methyltransferase in mammals, catalyzes
monomethylation and asymmetric dimethylation of arginine side chains in proteins. Initially …