The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …

Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disease that primarily
results from impaired insulin secretion or insulin resistance (IR). G protein-coupled receptors …

Regulator of protein signaling (RGS20) is a member of the RGS protein superfamily, which
serve as key negative regulators of G protein-mediated signal transduction. Through their …

The structural basis for the GTPase-accelerating activity of regulators of G protein signaling
(RGS) proteins, as well as the mechanistic basis for their specificity in interacting with the …

RGS6 and RGS7 are regulators of G protein signaling (RGS) proteins that inactivate
heterotrimeric (αβγ) G proteins and mediate diverse biological functions, such as cardiac …

The interactions of the antibiotic proteins colicins/pyocins with immunity proteins is a seminal
model system for studying protein–protein interactions and specificity. Yet, a precise and …

Regulator of G protein signaling (RGS) proteins have attracted attention as a result of their
primary role in directing the specificity as well as the temporal and spatial aspects of G …

Gαq is a ubiquitous molecular switch that activates the effectors phospholipase-C-β3 (PLC-
β3) and Rho guanine-nucleotide exchange factors. Gαq is inactivated by regulators of G …

Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in
signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS …

We combined computational and experimental methods to interrogate the binding
determinants of angiopoietin‐2 (Ang2) to its receptor tyrosine kinase (RTK) Tie2—a central …