Myelodysplastic syndromes
A Tefferi, JW Vardiman - New England Journal of Medicine, 2009 - Mass Medical Soc
This review gives an account of the clinical and hematologic features of the myelodysplastic
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …
Hedgehog signaling in the maintenance of cancer stem cells
CR Cochrane, A Szczepny, DN Watkins, JE Cain - Cancers, 2015 - mdpi.com
Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew
and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms …
and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms …
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
On the subject of acute myeloid leukemia (AML), there is little consensus about the target
cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic …
cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic …
Leukaemia stem cells and the evolution of cancer-stem-cell research
BJP Huntly, DG Gilliland - Nature Reviews Cancer, 2005 - nature.com
Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
BJP Huntly, H Shigematsu, K Deguchi, BH Lee… - Cancer cell, 2004 - cell.com
To better understand the origin of leukemic stem cells, we tested the hypothesis that all
leukemia oncogenes could transform committed myeloid progenitor cells lacking the …
leukemia oncogenes could transform committed myeloid progenitor cells lacking the …
Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate: Presented …
EL Sievers, FR Appelbaum… - Blood, The Journal …, 1999 - ashpublications.org
Leukemic blast cells express the CD33 antigen in most patients with acute myeloid leukemia
(AML), but this antigen is not expressed by hematopoietic stem cells. We conducted a study …
(AML), but this antigen is not expressed by hematopoietic stem cells. We conducted a study …
Acute myeloid leukemia
JE Rubnitz, B Gibson, FO Smith - Pediatric clinics of North America, 2008 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal
transformation of hematopoietic precursors through the acquisition of chromosomal …
transformation of hematopoietic precursors through the acquisition of chromosomal …
Human Acute Myeloid Leukemia CD34+/CD38− Progenitor Cells Have Decreased Sensitivity to Chemotherapy and Fas-induced Apoptosis, Reduced …
RT Costello, F Mallet, B Gaugler, D Sainty, C Arnoulet… - Cancer research, 2000 - AACR
The destruction of cells capable of initiating and maintaining leukemia challenges the
treatment of human acute myeloid leukemia. Recently, CD34+/CD38− leukemia progenitors …
treatment of human acute myeloid leukemia. Recently, CD34+/CD38− leukemia progenitors …
Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−
A Blair, DE Hogge… - Blood, The Journal of the …, 1998 - ashpublications.org
Acute myeloid leukemia (AML) occurs as the result of malignant transformation in a
hematopoietic progenitor cell, which proliferates to form an accumulation of AML blasts. Only …
hematopoietic progenitor cell, which proliferates to form an accumulation of AML blasts. Only …
Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem …
L Nilsson, I Åstrand-Grundström… - Blood, The Journal …, 2000 - ashpublications.org
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders
characterized by ineffective hematopoiesis and frequent progression to acute myeloid …
characterized by ineffective hematopoiesis and frequent progression to acute myeloid …