Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges

MH Rahman, J Bajgai, A Fadriquela, S Sharma… - Molecules, 2021 - mdpi.com
Natural products derived from plants, as well as their bioactive compounds, have been
extensively studied in recent years for their therapeutic potential in a variety of …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

[HTML][HTML] Oxidative stress at the crossroads of aging, stroke and depression

A Shao, D Lin, L Wang, S Tu, C Lenahan… - Aging and …, 2020 - ncbi.nlm.nih.gov
Epidemiologic studies have shown that in the aging society, a person dies from stroke every
3 minutes and 42 seconds, and vast numbers of people experience depression around the …

Compound Tongluo Decoction inhibits endoplasmic reticulum stress-induced ferroptosis and promoted angiogenesis by activating the Sonic Hedgehog pathway in …

Z Hui, S Wang, J Li, J Wang, Z Zhang - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Cerebral infarction is one of the most common types of
cerebrovascular diseases that threaten people's health. Compound Tongluo Decoction …

Muscone with Attenuation of Neuroinflammation and Oxidative Stress Exerts Antidepressant‐Like Effect in Mouse Model of Chronic Restraint Stress

H Liu, LL Liu, J Chen, YW Chen, Y Chai… - Oxidative Medicine …, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a common mental disorder with high morbidity. Stress
negatively affects for MDD development, whereby transport of stress‐induced inflammatory …

Neurobiological links between stress, brain injury, and disease

H Guo, L Zheng, H Xu, Q Pang, Z Ren… - Oxidative Medicine …, 2022 - Wiley Online Library
Stress, which refers to a combination of physiological, neuroendocrine, behavioral, and
emotional responses to novel or threatening stimuli, is essentially a defensive adaptation …

Anti-depressant-like effects of rannasangpei and its active ingredient crocin-1 on chronic unpredictable mild stress mice

Y Du, YL Wang, L Chen, QE Li, Y Cheng - Frontiers in Pharmacology, 2023 - frontiersin.org
Major depressive disorder is one of the most common neuropsychiatric diseases and it is a
global public health problem that leads to disabilities. Currently, there is a growing need to …

Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region

Z Zhao, L Xie, J Shi, T Liu, S Wang, J Huang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Zishen Huoxue Decoction (ZSHXD) is a
Traditional Chinese Medicine (TCM) prescription for the treatment of vascular dementia …

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio‐Cerebrovascular Ischemia and Depression

D Lin, L Wang, S Yan, Q Zhang… - … Medicine and Cellular …, 2019 - Wiley Online Library
The public health sector faces a huge challenge as a result of the high prevalence and
burden of disability caused by ischemic cardio‐cerebrovascular disease (CVD) and …

Paeoniflorin Rescued MK-801-Induced Schizophrenia–Like Behaviors in Mice via Oxidative Stress Pathway

JQ Liang, X Chen, Y Cheng - Frontiers in nutrition, 2022 - frontiersin.org
Schizophrenia (SCZ) affects approximately 1% population worldwide, and the first-line
antipsychotics have partial reactivity or non-reactivity with side effects. Therefore, there is an …