Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Opportunities and challenges in the delivery of mRNA-based vaccines

A Wadhwa, A Aljabbari, A Lokras, C Foged, A Thakur - Pharmaceutics, 2020 - mdpi.com
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …

RNA modifications in cancer

Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

The functions of microRNAs: mRNA decay and translational repression

H Iwakawa, Y Tomari - Trends in cell biology, 2015 - cell.com
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate
complementary mRNAs by inducing translational repression and mRNA decay. Although …

[HTML][HTML] Role of microRNAs in translation regulation and cancer

S Oliveto, M Mancino, N Manfrini… - World journal of biological …, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions.
They function by modulating transcriptional and translational programs and therefore they …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

MR Fabian, N Sonenberg - Nature structural & molecular biology, 2012 - nature.com
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to
function by post-transcriptionally regulating protein accumulation. Understanding how …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Angiogenin-induced tRNA fragments inhibit translation initiation

P Ivanov, MM Emara, J Villen, SP Gygi, P Anderson - Molecular cell, 2011 - cell.com
Angiogenin is a stress-activated ribonuclease that cleaves tRNA within anticodon loops to
produce tRNA-derived stress-induced fragments (tiRNAs). Transfection of natural or …

Regulation of mRNA translation and stability by microRNAs

MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …