There are 15 different DNA polymerases encoded in mammalian genomes, which are
specialized for replication, repair or the tolerance of DNA damage. New evidence is …

The human genome encodes at least 14 DNA-dependent DNA polymerases—a surprisingly
large number. These include the more abundant, high-fidelity enzymes that replicate the …

Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD)
and increased oxidative DNA damage has been observed in brain tissue from AD patients …

We have detected DNA polymerase beta (Pol β), known as a key nuclear base excision
repair (BER) protein, in mitochondrial protein extracts derived from mammalian tissue and …

We explore the role of DNA damage processing in the progression of cognitive decline by
creating a new mouse model. The new model is a cross of a common Alzheimer's disease …

Reactive oxygen species (ROS) arise from both endogenous and exogenous sources.
These reactive molecules possess the ability to damage both the DNA nucleobases and the …

Base excision repair (BER) is the major pathway for processing of simple lesions in DNA,
including single-strand breaks, base damage, and base loss. The scaffold protein XRCC1 …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

The major DNA repair pathway for coping with spontaneous forms of DNA damage, such as
natural hydrolytic products or oxidative lesions, is base excision repair (BER). In particular …

Base excision repair (BER) is a major DNA repair pathway employed in mammalian cells
that is required to maintain genome stability, thus preventing several human diseases, such …