Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for
generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for …

The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex
regulates gene expression at the level of chromatin. The NuRD complex has been identified …

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

Uterine serous carcinoma (USC) is a biologically aggressive subtype of endometrial cancer.
We analyzed the mutational landscape of USC by whole-exome sequencing of 57 cancers …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …