One of the most extended subfields of chemometrics, at least by considering the number of
publications and interested researchers, is QSAR/QSPR. During the time, various improved …

Objective: Novel bis (1, 4-dihydropyridine-3, 5-dicarbonitrile) derivatives linked to aliphatic
or aromatic cores via amide or ester-amide linkages were prepared and their structures …

Synthesis of novel tetrakis (2, 6-dimethyl-4-phenyl-1, 4-dihydropyridinyl) methanes 5a–d by
acid-catalyzed condensation of the tetrakis-aldehydes 6a–d with eight equivalents of 3 …

Abstract The precursor, piperazine-1, 4-diylbis (2-oxoethane-2, 1-diyl) bis (4-
formylbenzoate) was prepared by reacting 1, 1'-(piperazine-1, 4-diyl) bis (2-chloroethan-1 …

The molecular hybridization of various compounds with known pharmacological activity is a
particularly popular approach for the development of potential drugs with improved …

Targeting TGFβ/Smad signaling is an attractive strategy for several therapeutic applications
given its role as a key player in many pathologies, including cancer, autoimmune diseases …

Reaction of β-aminocrotonitrile with a series of bis (aldehydes) containing ether linkages
afforded the corresponding bis (2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarbonitrile) …

Aims From the synthesis of 43 lipophilic dihydropyridines, the aim of this study was to verify
whether the new dihydropyridines have calcium channel affinity using coupling studies and …

A novel series of bis (1, 4-dihydropyridine-3, 5-dicarbonitrile) and bis (tetrahydrodipyrazolo
[3, 4-b: 4′, 3′-e] pyridine) derivatives which are linked to pyrazole units were prepared via …

Das anhaltende Auftreten multiresistenter Krankheitserreger stellt die Wissenschaft vor
große Herausforderungen. Vor allem gramnegative Bakterien sind hierbei ein bedeutendes …