Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries
that reduces functional capacity and quality of life of patients. Despite relatively effective …

Glial cells (astrocytes, oligodendrocytes and microglia) are critical for the central nervous
system (CNS) in both physiological and pathological conditions. With this in mind, several …

Guanosine is a purine nucleoside with important functions in cell metabolism and a
protective role in response to degenerative diseases or injury. The past decade has seen …

Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

Guanosine is a purine nucleoside thought to have neuroprotective properties. It is released
in the brain under physiological conditions and even more during pathological events …

Glial cells are involved in multiple cerebral functions that profoundly influence brain tissue
viability during ischemia, and astrocytes are the main source of extracellular purines as …

The function of guanine-based purines (GBPs) is mostly attributed to the intracellular
modulation of heteromeric and monomeric G proteins. However, extracellular effects of …

Guanosine, a guanine-based purine, is an extracellular signaling molecule that is released
from astrocytes and has been shown to promote central nervous system defenses in several …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …

Accumulating evidences indicate that endogenous modulators of excitatory synapses in the
mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed …