Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …

This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout a man's life and
may have application for treating some cases of male infertility, including those caused by …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

This study was designed to isolate, characterize, and culture human spermatogonia. Using
immunohistochemistry on tubule sections, we localized GPR125 to the plasma membrane of …

Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes
onto the next generation. SSCs also have the potential to provide important knowledge …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …