Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Nobel lecture: Multiple equilibria
G Parisi - Reviews of Modern Physics, 2023 - APS
This is an extended version of my Nobel Lecture, delivered on December 8, 2021. I will
recall the genesis of the concept of multiple equilibria in natural sciences. I will then describe …
recall the genesis of the concept of multiple equilibria in natural sciences. I will then describe …
[HTML][HTML] Assessing the accuracy of physical models used in protein-folding simulations: quantitative evidence from long molecular dynamics simulations
Highlights•The accuracy of physical models used in protein-folding simulations is
assessed.•This assessment is based on data from very long molecular dynamics …
assessed.•This assessment is based on data from very long molecular dynamics …
Protein design: toward functional metalloenzymes
F Yu, VM Cangelosi, ML Zastrow, M Tegoni… - Chemical …, 2014 - ACS Publications
Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …
protein structure and function. The field of protein design has seen significant progress over …
Converging concepts of protein folding in vitro and in vivo
FU Hartl, M Hayer-Hartl - Nature structural & molecular biology, 2009 - nature.com
Most proteins must fold into precise three-dimensional conformations to fulfill their biological
functions. Here we review recent concepts emerging from studies of protein folding in vitro …
functions. Here we review recent concepts emerging from studies of protein folding in vitro …
Inverse statistical physics of protein sequences: a key issues review
In the course of evolution, proteins undergo important changes in their amino acid
sequences, while their three-dimensional folded structure and their biological function …
sequences, while their three-dimensional folded structure and their biological function …
Cotranslational protein folding inside the ribosome exit tunnel
OB Nilsson, R Hedman, J Marino, S Wickles, L Bischoff… - Cell reports, 2015 - cell.com
At what point during translation do proteins fold? It is well established that proteins can fold
cotranslationally outside the ribosome exit tunnel, whereas studies of folding inside the exit …
cotranslationally outside the ribosome exit tunnel, whereas studies of folding inside the exit …
SMOG 2: a versatile software package for generating structure-based models
Molecular dynamics simulations with coarse-grained or simplified Hamiltonians have proven
to be an effective means of capturing the functionally important long-time and large-length …
to be an effective means of capturing the functionally important long-time and large-length …
Water mediation in protein folding and molecular recognition
Y Levy, JN Onuchic - Annu. Rev. Biophys. Biomol. Struct., 2006 - annualreviews.org
Water is essential for life in many ways, and without it biomolecules might no longer truly be
biomolecules. In particular, water is important to the structure, stability, dynamics, and …
biomolecules. In particular, water is important to the structure, stability, dynamics, and …
The multiscale coarse-graining method. I. A rigorous bridge between atomistic and coarse-grained models
Coarse-grained (CG) models provide a computationally efficient method for rapidly
investigating the long time-and length-scale processes that play a critical role in many …
investigating the long time-and length-scale processes that play a critical role in many …