Thienopyrimidines are widely represented in the literature, mainly due to their structural
relationship with purine base such as adenine and guanine. This current review presents …

Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Background Alzheimer's disease (AD), the most common cause of dementia in the elderly, is
a progressive neurodegenerative disorder that gradually affects cognitive function and …

Introduction: Artocarpus altilis leaves extract has previously been reported as a potential
antimalarial drug. Inhibition concentration (IC 50) against P. falciparum and effective dose …

Malaria is among the leading causes of death worldwide. The emergence of Plasmodium
falciparum resistant strains with reduced sensitivity to the first line combination therapy and …

In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric
stilbenoids,(–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) and their monomeric …

Allosteric inhibitors regulate enzyme activity from remote and usually specific pockets. As
they promise an avenue for less toxic and safer drugs, the identification and characterization …

Malaria is a devastating infectious disease that affects large swathes of human populations
across the planet s tropical regions. It is caused by parasites of the genus Plasmodium, with …

We report computer-aided design of new lactone–chalcone and isatin–chalcone (HLCIC)
inhibitors of the falcipain-2 (Pf FP-2). 3D models of 15 FP-2: HLCIC1-15 complexes with …

The emergence of drug‐resistant strains of Plasmodium falciparum is the worst catastrophe
that has ever confronted the dedicated efforts to eradicate malaria. This urged for searching …