Mammalian stem cells govern development, tissue homeostasis, and regeneration.
Following years of study, their functions have been delineated with increasing precision. The …

Giant cell arteritis (GCA) is a prototypic autoimmune disease with a highly selective tissue
tropism for medium and large arteries. Extravascular GCA manifests with intense systemic …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Cancer is a major cause of death globally, and traditional treatments often have limited
efficacy and adverse effects. Immunotherapy has shown promise in various malignancies …

Stem‐like T cells are characterized by their ability to self‐renew, survive long‐term, and give
rise to a heterogeneous pool of effector and memory T cells. Recent advances in single‐cell …

Transcription factors (TFs) constitute an essential component of epigenetic regulation. They
contribute to the progression of vascular diseases by regulating epigenetic gene expression …

Giant cell arteritis (GCA), the most common systemic vasculitis, is characterised by aberrant
interactions between infiltrating and resident cells of the vessel wall. Ageing and breach of …

The intestinal immune system must establish tolerance to food antigens to prevent onset of
allergic and inflammatory diseases. Peripherally generated regulatory T (pTreg) cells play …