Major developments in research into the azole class of antifungal agents during the 1990s
have provided expanded options for the treatment of many opportunistic and endemic fungal …

The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …

With increasing numbers of immune-compromised patients with malignancy, hematologic
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …

The Fifth Edition of this highly acclaimed reference describes state-of-the-art laboratory
methods for evaluating the efficacy of antibiotics and the mechanisms of bacterial resistance …

An 8-person subcommittee of the National Institute of Allergy and Infectious Diseases
(NIAID) Mycoses Study Group evaluated available data on the treatment of cryptococcal …

Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

Background It frequently takes more than 2 weeks for drug treatments for cryptococcal
meningitis to sterilise cerebrospinal fluid (CSF). In-vitro and animal studies lend support to …

Cryptococcus neoformans strains classically have been grouped into two varieties that
included five serotypes known as C. neoformans variety neoformans (serotypes A, D, and …

The development of natural protective agents as alternatives to chemical fungicides is
currently in the spotlight. In the present investigation, chemical composition and antifungal …

The central nervous system (CNS) distribution and antifungal efficacy of all 4 approved
formulations of amphotericin B (AmB) were investigated in a rabbit model of hematogenous …