Chemokines belong to the family of cytokines with chemoattractant properties that regulate
chemotaxis and leukocyte migration, as well as the induction of angiogenesis and …

ABSTRACT SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19
patients experience sudden and rapid deterioration with the onset of fatal cytokine storm …

The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results
in inflammation and demyelination of the central nervous system (CNS). MS symptoms …

Background Sarcomas, cancers originating from mesenchymal cells, are comprehensive
tumors with poor prognoses, yet their tumorigenic mechanisms are largely unknown. In this …

Liver failure profoundly affects the immune system, leading to dysregulation of innate and
adaptive immune response. This review explores the intricate relationship between liver …

Chemokine receptors are integral to the immune system and prime targets in drug discovery
that have undergone extensive structural elucidation in recent years. We outline a timeline of …

Chemokines are a family of signaling proteins that play a crucial role in cell–cell
communication, cell migration, and cell trafficking, particularly leukocytes, under both normal …

Interactions between interleukin (IL)-8 and its receptors, CXCR1, and CXCR2, serve crucial
roles in inflammatory conditions and various types of cancers. Inhibition of this signaling …

AlphaFold and AlphaFold-Multimer have become two essential tools for the modeling of
unknown structures of proteins and protein complexes. In this work, we extensively …